A Review: Impact of Higher Doses of Testosterone on Muscle Mass

Results from a 20-Week Study on 60 Healthy Young Men

Testosterone enanthate has been a popular hormone supplement for men looking to build muscle mass and strength. A recent study conducted by American researchers and published in the American Journal of Physiology – Endocrinology and Metabolism has revealed the impact of different doses of testosterone enanthate on muscle mass and potential side effects.

Methods

To conduct the study, the researchers used a GnRH-agonist named Decapeptyl to deactivate testosterone production in 60 healthy men between the ages of 18 and 35 who had prior weight-lifting experience. These men were then given a 20-week course of testosterone enanthate injections with weekly doses of 25, 50, 125, 300, or 600 mg. It should be noted that 25 mg is considered the minimum dose needed to maintain normal sexual functioning in men, while 600 mg is considered the maximum dose that can be safely injected without incurring any acute medical problems.

Results

The results showed that the higher the testosterone dose, the more fat-free mass the men developed. Additionally, their leg-press strength increased as the testosterone dose increased. There was no significant effect on the men’s sexual activities, regardless of the dose.

The researchers were concerned about the relationship between anabolic hormones and cancer, specifically the effects on the prostate. A marker for prostate condition, the prostate cancer protein PSA, was monitored, but there was no significant increase in PSA levels among the men who received higher doses of testosterone.

However, the higher doses of testosterone did have a small impact on the “good” HDL cholesterol. The researchers concluded that while testosterone isn’t completely safe, the potential side effects are manageable. They suggest the development of SARMs (selective androgen receptor modulators) as a safer alternative that can selectively enhance muscle mass and strength without having significant effects on prostate and cardiovascular risk factors.

The results showed that as the testosterone dose increased, so did fat-free mass and leg-press strength. Furthermore, there was no significant effect on sexual activities regardless of the dosage amount administered. This suggests that testosterone can be safely used to increase muscle mass without having any adverse effects on reproductive health. However, caution must be taken when using higher doses of testosterone as there may be potential side effects associated with prolonged use. It is important to consult with a physician prior to starting any hormone supplement or changing dosages in order to ensure safety and optimal results.

In conclusion, the results of this study show that testosterone enanthate can be used to increase muscle mass and strength without having any adverse effects on reproductive health. However, caution must be taken when using higher doses as there may be potential side effects associated with prolonged use. The researchers suggest the development of SARMs (selective androgen receptor modulators) as a safer alternative for those looking to enhance muscle mass and strength without incurring additional risks from elevated levels of anabolic hormones in their body. With proper guidance from medical professionals, individuals can benefit from supplementing with testosterone enanthate safely while avoiding unnecessary risk factors.